Probing Sexual Transformation of the Human Malaria Parasite,plasmodium Falciparum,using Novel Imaging Modalities

Role of plasmodium falciparum protein GEXP07 in Maurer’s Cleft morphology, Knob architecture, and P. Falciparum EMP1 trafficking

E McHugh, OMS Carmo, A Blanch, O Looker, B Liu, S Tiash, D Andrew, S Batinovic, AJY Low, HJ Cho, P McMillan, L Tilley, MWA Dixon

2020-01-01

The malaria parasite Plasmodium falciparum traffics the virulence protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) to..

The knob protein KAHRP assembles into a ring-shaped structure that underpins virulence complex assembly

O Looker, AJ Blanch, B Liu, J Nunez-Iglesias, PJ McMillan, L Tilley, MWA Dixon

2019-05-01

Plasmodium falciparum mediates adhesion of infected red blood cells (RBCs) to blood vessel walls by assembling a multi-protein com..

Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development

M Parkyn Schneider, B Liu, P Glock, A Suttie, E McHugh, D Andrew, S Batinovic, N Williamson, E Hanssen, P McMillan, M Hliscs, L Tilley, MWA Dixon

2017-10-01

Transmission of malaria parasites relies on the formation of a specialized blood form called the gametocyte. Gametocytes of the hu..

A Plasmodium falciparum S33 proline aminopeptidase is associated with changes in erythrocyte deformability

FL da Silva, MWA Dixon, CM Stack, F Teuscher, E Taran, MK Jones, E Lovas, L Tilley, CL Brown, KR Trenholme, JP Dalton, DL Gardiner, TS Skinner-Adams

2016-10-01

Infection with the apicomplexan parasite Plasmodium falciparum is a major cause of morbidity and mortality worldwide. One of the s..

Comparison of the exposure time dependence of the activities of synthetic ozonide antimalarials and dihydroartemisinin against K13 wild-type and mutant Plasmodium falciparum Strains

T Yang, SC Xie, P Cao, C Giannangelo, J McCaw, DJ Creek, SA Charman, N Klonis, L Tilley

2016-08-01

Fully synthetic endoperoxide antimalarials, namely, OZ277 (RBx11160; also known as arterolane) and OZ439 (artefenomel), have been ..

Reversible host cell remodeling underpins deformability changes in malaria parasite sexual blood stages

M Dearnley, T Chu, Y Zhang, O Looker, C Huang, N Klonis, J Yeoman, S Kenny, M Arora, JM Osborne, R Chandramohanadas, S Zhang, MWA Dixon, L Tilley

2016-04-26

The sexual blood stage of the human malaria parasite Plasmodium falciparum undergoes remarkable biophysical changes as it prepares..

Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins

SC Xie, C Dogovski, E Hanssen, F Chiu, T Yang, MP Crespo, C Stafford, S Batinovic, S Teguh, S Charman, N Klonis, L Tilley

2016-01-01

Current first-line artemisinin antimalarials are threatened by the emergence of resistant Plasmodium falciparum. Decreased sensiti..

Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance

C Dogovski, SC Xie, G Burgio, J Bridgford, S Mok, JM McCaw, K Chotivanich, S Kenny, N Gnädig, J Straimer, Z Bozdech, DA Fidock, JA Simpson, AM Dondorp, S Foote, N Klonis, L Tilley

2015-04-22

Successful control of falciparum malaria depends greatly on treatment with artemisinin combination therapies. Thus, reports that r..

Organization and function of an actin cytoskeleton in Plasmodium falciparum gametocytes

M Hliscs, C Millet, MW Dixon, I Siden-Kiamos, P Mcmillan, L Tilley

2015-02-01

In preparation for transmission to its mosquito vector, Plasmodium falciparum, the most virulent of the human malaria parasites, a..